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Saliva Hormone Test for Estrone
Estrone is one of the
three naturally occurring estrogens, the others being estradiol and estriol.
Estrone is produced primarily from androstenedione originating from the
gonads or the adrenal cortex. In premenopausal women, more than 50% of the
estrone is secreted by the ovaries. In prepubertal children, men and
non-supplemented postmenopausal women the major portion of estrone is
derived from peripheral tissue conversion of androstenedione.
Interconversion of estrone and estradiol also occurs in peripheral tissue.
Bioassay data indicate
that the estrogenic action is much less than estradiol. Estrone is a primary
estrogenic component of several pharmaceutical preparations, including those
containing conjugated and esterified estrogens. In premenopausal women
estrone levels generally parallel those of estradiol. After menopause
estrone levels increase, possibly due to increased conversion of androstenedione to estrone.
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